April 21, 2017
In either of these scenarios, smaller T1 volumes (higher pre baseline degeneration) in the source region should predict larger magnitudes of volumetric decrease (higher post baseline degeneration) in the target region, yielding a negative relationship (see Fig. 3c). Based on existing models of AD progression41,42,43, we predicted that the rate of change in GM degeneration would follow a nonlinear sigmoid shape.
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